You answered: High-grade squamous intra-epithelial lesion
           That is CORRECT!

CYTOPATHOLOGY:

• Disordered and irregular aggregates of highly atypical cells are present
• Cell crowding is readily apparent, with altered nuclear polarity
• Cytoplasm is scant to absent in many groups, while other clusters have well-defined, dense basophilic cytoplasm
• The nuclei are irregular and hyperchromatic

DISCUSSION:

• The cervical biopsy reveals a high-grade squamous intra-epithelial lesion.
• Interpretation of crowded cell clusters can be very difficult.  Looking for hyperchromatic nuclei, irregular nuclear membranes, and dense cytoplasm would aid in the diagnosis of a squamous lesion.
• Nuclear palisading can be seen in fragments from squamous carcinoma in situ and in the absence of definite gland formation, rosettes or feathering, are more likely squamous than endocervical.

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REFERENCES:

Bonfiglio TA, Erozan YS. Gynecologic Cytopathology. Philadelphia: Lipincott-Raven 1997:145.

Solomon D, Nayar R et al. The Bethesda System for Reporting Cervical Cytology 2nd Edition. New York: Springer-Verlag 2004: 80-81.