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07 Phylloides Tumours of Breast (Cystosarcoma Phyloides)
Updated: 25 August 2005
These uncommon sarcomas of the female breast arise from the stromal elements. Histologically they may be categorized to be benign or malignant. Adenocarcinoma may co-exist and therefore pathology review of these tumours is recommended. Wide local excision (at least 2 cm of histologically normal breast tissue margin and/or a clearly defined fascial boundary) is the treatment of choice for phylloides tumours. If the lesion is deep in the breast the excision must include fascia. Specimens should be inked so their margins can be assessed for involvement by tumour. A phylloides tumour should be suspected if a fibroadenoma is "recurrent." A pathology review at BCCA may be helpful. As lymph node metastases are rare, in the absence of adenocarcinoma elements, axillary node dissection is not recommended. Local recurrences may predict for development of metastases even in patients with "benign" disease. Metastases are generally to lung although bone and liver involvement may occur. Patients with more aggressive histology may be offered radiation therapy to improve local control rates. There is no known role for chemotherapy in the adjuvant setting.
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