(Prostate section revised 26 March 2001)

Digital rectal examination and tumour marker measurement in the form of PSA are recommended at regularly scheduled intervals (e.g. three-monthly in the first year, increasing to six-monthly). Elevation of PSA (see definitions below), or a palpable nodule (biopsy confirmed) suggests disease recurrence and that local radiotherapy or hormonal therapy may be considered. Patients with positive margins or capsular penetration may benefit from adjuvant therapy (under clinical trials at present). Such patients should be referred for an oncologic opinion.