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Hereditary Cancer Rounds
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WHAT: |
Hereditary Cancer Rounds are an accredited Group Learning Activity (Section 1) as defined by the Maintenance of Certification program of the Royal College of Physicians and Surgeons of Canada.
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| WHO: |
Health care professionals who work with hereditary cancer families and/or have an interest in cancer genetics. |
| WHY: |
To promote information exchange across disciplines.
To share expert knowledge and experience between specialists who care for individuals and families living with hereditary cancer. |
WHEN: |
2nd Friday of each month (September - June), 0800-0900 |
| WHERE: |
4th floor Board Room, Vancouver Centre, BCCA, 600 West 10th Ave
Video-linked to other sites on request. |
Upcoming Hereditary Cancer Rounds
May 11, 2012 - CANCELLED (speaker unavailable)
June 8, 2012 - Topic and speaker to be confirmed
Previous Hereditary Cancer Rounds - available for viewing via hyperlinks below
April 13, 2012
Hereditary Cancer Program's High-Risk (Breast) Clinic: Experience to Date
Melissa Laing, Nurse Practitioner & Mary McCullum, Nurse Educator
Hereditary Cancer Program, BC Cancer Agency
Objectives:
1) review the clinic's first (almost) 15 years of experience with high-risk screening for women wtih confirned BRCA1/2 gene mutations
2) discuss related clinical challenges
link to recording to be added
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March 9, 2012
British Columbia's Personalized Medicine Initiative: Next Generation Sequencing & the Personalization of Cancer Control
Dr David Huntsman, BC Cancer Agency
Objectives
http://learn.phsa.ca/bcca/hcp/rounds2012mar9/HCP2012MAR9_flv_loader.html
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February 10, 2012
Telomeres & Hereditary Cancer
Dr Geraldine Aubert & Dr Mark Hills
Objectives:
1) introduction to telomere biology & telomere deficiency syndromes
2) telomere deficiency syndromes & cancer risk
3) cancer types with established links to hereditary cancer & teleomere deficiency
4) what are the genes involved? application of next generation sequencing approaches in translational research
http://learn.phsa.ca/bcca/hcp/rounds2012feb10/HCP_Rounds_10feb2012_flv_loader.html
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January 13, 2012
Case Discussions
lab & clinic presentations - not recorded
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December 9, 2011
Highlights from Recent Conferences
- 12th International Congress of Human Genetics
- Canadian Association of Genetic Counsellors
Carol Cremin, genetic counsellor, Hereditary Cancer Program, BCCA
Objectives:
1) to review highlights from the conferences
2) to discuss implications for practice
http://learn.phsa.ca/BCCA/HCP/Rounds2011Dec9/HCP_9dec2011_flv_loader.html
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November 25, 2011 (instead of November 11)
Highlights from Recent Conferences
- National Society of Genetic Counselors, 30th Annual Conference
MJ Hunter, genetic counsellor, Hereditary Cancer Program, BCCA
- Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC), 15th Annual Meeting
Stephanie Desmarais, genetic counsellor, Alberta Children's Hospital
Objectives:
1) to review highlights from the conferences
2) to discuss implications for practice
http://learn.phsa.ca/BCCA/HCP/Rounds2011Nov25/HCP_25nov2011_flv_loader.html
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October 14, 2011
Hereditary pheochromocytoma & paraganglioma: Updates from 3rd international symposium
Jennifer Nuk, genetic counsellor, Hereditary Cancer Program, BCCA
Objectives:
1) review recent discovery of additional genes predisposing to PHEO/PGL
2) discuss current recommendations and strategies for genetic testing
3) bring awareness to current challenges and controversies in screening and management
http://learn.phsa.ca/bcca/hcp/rounds2011oct14/BCCA%20HCP%20Rounds_14oct2011_flv_loader.html
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September 9, 2011
BRCA1/2 UCV assessment: uncertainty going backwards & forwards
Dr Ian Wilson, CCMG Molecular Genetics Fellow, BCCA
Objectives:
1) gain familiarity with the principles of some of the software used for missense variant and splicing prediction in UCVs
2) understand the limitations of this type of analysis and where a combined computed prediction will be useful
http://learn.phsa.ca/bcca/hcp/rounds2011sep9/HCP_Rounds_9sept2011_flv_loader.html
June 10, 2011
Second-Generation Sequencing for Clinical Diagnostics
Dr Ian Bosdet, clinical scientist, Cancer Genetics Laboratory, BCCA
Objectives:
1) briefly review second-generation sequencing technology
2) discuss common methods for identifying sequence variants and chromosome structure changes
http://learn.phsa.ca/bcca/hcp/rounds2011jun10/BCCA_HCP_Rounds_10june2011_flv_loader.html
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May 13, 2011 - Presentation of 2 MSc Genetic Counselling Directed Studies Projects
A. Exploring the lived experience after a diagnosis of Li Fraumeni syndrome (LFS)
Kirsten Bartels, genetic counsellor
Objectives:
1) review LFS and previous LFS psychosocial literature
2) present results of this qualitative study of the psychosocial experience of individuals since their genetic diagnosis of LFS
3) discuss the significance of the study results and opportunities for future research
slides  for review as no recording available
B. Incident testing for Lynch syndrome in colorectal cancer (CRC) under age 50 in BC
Nasim Moradi-Monfared, genetic counsellor
Objectives:
1) determine the utilization rate of MSI testing in BC patients with CRC under age 50 from June1/08-Aug 30/09
2) compare MSI testing utilization rates in "HCP group" (patients who received genetic counselling/testing via Hereditary Cancer Program) vs "incident group" (patients with CRC dx <50, referred to BCCA only)
3) compare demographic and clinicopathologic characteristics of patients in HCP and incident groups
slides for review as no recording available
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April 8, 2011
Management of proliferative lesions of the breast (ADH, ALH, DIN1a & b, LCIS, DCIS)
Dr Urve Kuusk, medical director, Mt St Joseph's Rapid Access Breast Clinic & surgical oncologist, BCCA
Learning points:
1) what to do with atypia found on stereotactic core biopsy
2) atypia found on open biopsy - risk of future cancer development and treatment options
3) LCIS and DCIS - treatment options
http://learn.phsa.ca/BCCA/HCP/Rounds2011apr8/BCCA_HCP_Rounds_8apr2011_flv_loader.html
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March 11, 2011
Can we define patients who will respond to PARP inhibitors?
Dr Karen Gelmon, medical oncologist, BCCA
Objectives:
1) discuss the rationale for treatment with PARP inhibitors
2) discuss the outcome of a multicentre Canadian trial of Olaparib, an oral PARP inhibitor
3) discuss current directions in development of PARP inhibitors
http://learn.phsa.ca/BCCA/HCP/Rounds2011mar11/BCCA_HCP_Rounds_11mar2011_flv_loader.html
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February 11, 2011
Reducing the burden of gynecologic cancers in hereditary cancer syndromes
Dr Janice Kwon, gynecologic oncologist, Vancouver General Hospital & BCCA
Objectives:
1) review the risks of gyne cancers associated with BRCA and Lynch syndrome
2) discuss methods to improve the identification of potential carriers
3) describe risk-reducing interventions and management of adverse effects
http://learn.phsa.ca/BCCA/HCP/Rounds2011feb11/BCCA_HCP_Rounds_11feb2011_flv_loader.html
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January 14, 2011
Determination of a family's tie between bones and blindness: A next-generation sequencing approach
Dr Intan Schrader, UBC Medical Genetics & BCCA
Objectives:
1) increase awareness & knowledge of strategies to facilitate disease diagnosis
2) consider the potential use of novel gene identification in the hereditary cancer setting
http://learn.phsa.ca/BCCA/HCP/Rounds2011jan14/BCCA_HCP_Rounds_14jan2011_flv_loader.html
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December 10, 2010
Highlights from Recent Conferences
MJ Hunter & Barbara Boyd, genetic counsellors, Hereditary Cancer Program,BCCA
Objectives:
1) review highlights from the following recent conferences:
- Collaborative Group of the Americas Inherited Colorectal Cancer (CGA-ICC)
- National Society of Genetic Counselors
2) discuss implications for local practice
http://learn.phsa.ca/bcca/hcp/rounds2010dec10/BCCA_HCP_Rounds_10dec2010_flv_loader.html
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November 12, 2010
Highlights from Recent Conferences
Jennifer Nuk & Carol Cremin, genetic counsellors, Hereditary Cancer Program, BCCA
Objectives:
1) review highlights from the following recent conferences:
- American Society of Human Genetics (ASHG)
- Canadian Association of Genetic Counsellors (CAGC)
- Li-Fraumeni Syndrome: A Multidisciplinary State-of-the-Science Conference
2) discuss implications for local practice
http://learn.phsa.ca/bcca/hcp/rounds2010nov12/BCCA%20HCP%20Rounds_12nov2010_flv_loader.html
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September 10, 2010
Hyperplastic polyposis and MYH
Dr Cristina Dias, medical geneticist, Hereditary Cancer Program,BCCA
Objectives:
1) review current literature on hyperplastic polyposis syndrome
2) discuss the Hereditary Cancer Program's approach to hyperplastic polyposis referrals
3) discuss current Hereditary Cancer Program criteria for MYH testing
http://learn.phsa.ca/bcca/hcp/rounds2010sept10/BCCA HCP Rounds_10sept2010_flv_loader.html |
June 11, 2010 - Regular time & location
Psychosocial Impact of Genetic Testing in Cancer: Screening for Those who Require Additional Psychosocial Support
Dr Mary Jane Esplen, Head of Psychosocial and Psychotherapy Research in Cancer Genetics, Toronto General Research Institute
Objectives:
1) increase awareness of issues associated with psychosocial impacts of genetic testing
2) increase knowledge of specific markers for adjustment difficulties
3) increase knowledge of tools or strategies to facilitate adjustment
http://learn.phsa.ca/bcca/hcp/Rounds2010jun11/HCP%20Rounds_11june2010_flv_loader.html |
June 11, 2010 - Co-hosted with BC Pancreatic Cancer Research Net at a special time & location
Pancreatic Cancer - Progress - Finally
Dr Steven Gallinger, Senior Investigator, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto
Objectives:
1) discuss emerging clinical & research questions in pancreatic cancer
2) highlight work with the International Cancer Genome Consortium
http://learn.phsa.ca/bcca/hcp/sRounds2010jun11/BCCA%20-%20Special%20HCP%20Rounds_11june2010_flv_loader.html |
May 14, 2010
Pathology of Hereditary Ovarian Cancer
Dr Blake Gilks, pathologist, Vancouver General Hospital
Objectives:
1) recognize histopathological diagnoses (subtypes of ovarian cancer) in pathology reports that are/are not associated with increased likelihood of hereditary breast/ovarian cancer (BRCA1/2) or Lynch syndrome (HNPCC)
2) learn about the pathological features of early "ovarian" cancer, particularly as it presents in risk-reducing salpingo-oophorectomy specimens
http://learn.phsa.ca/bcca/hcp/Rounds2010may14/HCP%20Rounds_14may2010_edit2_flv_loader.html |
April 9, 2010
Expedited BRCA1/2 Testing in Incident Breast Cancer Care
Dr Stephen Chia, medical oncologist, BCCA
Jenna Scott, genetic counsellor, Hereditary Cancer Progam,BCCA
Objectives:
1) present an oncology perspective of expedited BRCA results for newly diagnosed breast cancer patients
2) review the BCCA experience with expedited BRCA testing to date
3) highlight relevant genetic counselling issues for this patient population
http://learn.phsa.ca/bcca/hereditarycancer/hcp2/HCP2_flv_loader.html |
March 12, 2010
Updates: Lynch Syndrome in BC and Colon Check
Carol Cremin, genetic counsellor, Hereditary Cancer Program, BCCA
Laura Sware, manager, Colon Check, BCCA
Objectives:
1) review local Lynch syndrome experience & future directions
2) introduce the Colon Check program - target areas, preliminary results, and plans for 2010/2011
http://learn.phsa.ca/bcca/hereditarycancer/hcp1/HCP_flv_loader.html |
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