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HBOC Criteria
posted May 8, 2009
The following definitions apply to referrals for Hereditary Breast* and/or Ovarian** Cancer:
* breast cancer excludes LCIS (lobular carcinoma in situ); includes DCIS (ductal carcinoma in situ), depending on age & grade - see table below to assess eligibility:
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Grade |
Adjustment factor (for approximate age at invasive disease) |
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high grade DCIS (grade 3) |
add 3 yrs to age at DCIS diagnosis |
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intermediate grade DCIS (grade 2) |
add 5 years to age at DCIS diagnosis |
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low grade DCIS (grade 1) |
add 10 years to age at DCIS diagnosis |
** ovarian cancer refers to invasive non-mucinous epithelial ovarian cancer
includes cancer of the fallopian tubes or primary peritoneal cancer
excludes borderline/LMP ovarian tumours
Referral Criteria: Hereditary Breast and/or Ovarian Cancer
Return to Referral Form
| Confirmed BRCA1 or BRCA2 gene mutation in a close family member |
- if possible, provide a copy of family member's test report with referral
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Your patient's personal history
1) Refer to definitions of breast & ovarian cancer above.
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- breast cancer < age 35, or
- 2 primary breast cancers with at least 1 diagnosed < age 50, or
- ovarian cancer at any age
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Your patient's family history (this may include your patient's cancer diagnosis)
1) Refer to definitions of breast & ovarian cancer above.
2) Close relatives include children, brothers, sisters, parents, aunts, uncles, grandchildren & grandparents on the same side of the family.
3) History of cancer in cousins and more distant relatives from the same side of the family may also be relevant.
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- 1 breast cancer and 1 ovarian cancer in close relatives, or
- 1 male breast cancer and 1 breast or ovarian cancer in close relatives, or
- 2 close relatives with breast cancer, both diagnosed < age 50, or
- 2 close relatives with ovarian cancer, or
- 3 breast cancers in close relatives, with 1 diagnosed < age 50
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Ashkenazi Jewish heritage
1) Refer to definitions of breast & ovarian cancer above.
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- personal or family history of breast or ovarian cancer
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