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5. Staging (mesothelioma)
May need to update to the AJCC 6th Edition
UICC Staging 1997
| I |
Disease confined within the capsule of the parietal pleura: ipsilateral pleura, lung, pericardium, and diaphragm. |
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T1 N0 MO |
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T2 N0 M0 |
| II |
All of stage I with positive intrathoracic (N1 or N2) lymph nodes. |
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T1 N1 M0 |
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T2 N1 M0 |
| III |
Local extension of disease into the following: chest wall or mediastinum: heart or through the diaphragm, periotoneum; with or without extrathoracic or contralateral (N3) lymph node involvement. |
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T3 NO MO |
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T3 N1 M0 |
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T1 N2 M0 |
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T2 N2 M0 |
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T3 N2 M0 |
| IV |
Distant metastatic disease |
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Any T N3 MO |
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T4 any N M0 |
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Any T and N M1 |
| T |
(Primary Tumour and Extent) |
| TX |
Primary tumour cannot be assessed |
| T0 |
No evidence of primary tumour |
| T1 |
Primary tumour limited to ipsilateral parietal or visceral pleura |
| T2 |
Tumour invades any of the following: ipsilateral lung, endothoracic fascia, diaphragm, pericardium |
| T3 |
Tumour invades any of the following: ipsilateral chest wall muscle, ribs, mediastinal organs or tissues |
| T4 |
Tumour extends to any of the following: contralateral pleura or lung by direct extension, peritoneum or intra-abdominal organs by direct extension, cervical tissues |
| N |
(Lymph Nodes) |
| NX |
Regional lymph nodes cannot be assessed |
| NO |
No regional lymph nodes metastases |
| N1 |
Metastases in ipsilateral bronchopulmonary of hilar lymph nodes |
| N2 |
Metastases in ipsilateral mediastinal lymph nodes |
| N3 |
Metastases in contralateral mediastinal internal mammary, supraclavicular, or scalene lymph nodes |
| M |
(Metastases) |
| MX |
Presence of distant metastases cannot be assessed |
| M0 |
No known distant metastases |
| M1 |
Distant metastasis present |
5.2 Staging Diagram 
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