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6. Dose Modifications
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| Dosage Modification for Myelosuppression |
Effective date: Sept. 1/94 |
Dosage Modification for Myelosuppression
Adjust dosage according to the protocol by which the patient is being treated.
If no guidelines available, modify dosage as follows:
PLATELET COUNT
(x 109/L) |
ABSOLUTE NEUTROPHIL (ANC)*
(x 109/L) |
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> 1.8 |
1.5-1.8 |
1.0-1.5 |
<1.0 |
> 100
70-100
50-70
<50 |
100%
75%
50%
0% |
75%
75%
50%
0% |
50%
50%
50%
0% |
0%
0%
0%
0% |
* ANC = WBC x (% polys + % stabs)
** 0% Indicates treatment should be postponed a week until the counts return to a level at which drugs may be given.
Example: For an absolute neutrophil count of 1.3 x 109L and a platelet count of 135 x 109L, 50% dose of the total dose of all chemotherapy drugs should be given. This is 50% of the previously determined 100% dose, not of the previously given dose. |
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