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Angiofollicular Lymph node hyperplasia (Castleman's Disease)

Angiofollicular lymph node hyperplasia occurs as two histologic subtypes - the hyaline-vascular type and the plasma cell variant. The hyaline-vascular type is usually localized and not associated with systemic symptoms and is best managed with complete surgical excision. The plasma cell variant accounts for approximately 10% of cases and is often accompanied by systemic symptoms. Management of this entity should be discussed with a medical oncology member of the Lymphoma Tumour Group at one of the BCCA Centers. A multicentric form of Castleman's disease exists with histologic features that overlap both hyaline-vascular and plasma cell variants. The malignant potential of this systemic disease is uncertain and management should be individualized.

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