Patients with MGUS are at risk to develop lymphoproliferative diseases such as myeloma or malignant lymphoma. They should be re-examined annually and at those times the following tests should be obtained:

• CBC, serum creatinine, calcium
• Serum and 24 h urine protein electrophoreses
• Skeletal survey (optional after 3-5 years of observation with no evidence of progression)​​​​