Squamous Cell Carcinoma Associated Antigen is a tumour marker purified from human squamous cell carcinoma tissue of the uterine cavity. It is primarily used as a marker for squamous cell carcinoma of the cervix and uterus. However, it is also seen in cancers of the anus, vagina, vulva, lung, esophagus, skin, head and neck. SCC is primarily used as a monitor of response to therapy.

SCC is a chemiluminescent magnetic microparticle immunoassay (CMIA) performed on the Abbott ARCHITECT platform. Samples can be serum (preferred) or plasma.

Reference Range = < 1.5 µg/L

Interferences: Human anti-mouse antibodies (HAMA), saliva, other body fluids. SCC samples are very easily contaminated and must be handled with care.​​