The correct answer is 3.
Rationale: Based on GOOVCATX protocol, "Dose Modification, Hematology": If ANC is greater than or equal to 1.5, and Platelets are greater than or equal to 100 at nadir, the dose of PACLitaxel is given at 100% and CARBOplatin is given at 120%. Note that this is 120% of the dose from the previous cycle that was calculated based on the renogram GFR.
As per BC Cancer Policy III-10, the BSA calculated at Cycle 1 is used for subsequent cycles, so PACLitaxel dose does not change.
Calculated dose of CARBOplatin:
120% x 810 mg = 972 mg
Dose ordered by physician = 945 mg
Difference between the 2 doses: 972 – 945 = 27
27/945 x 100% = 2.9%
There is less than 5% difference between the two calculated doses, so the dose ordered is acceptable.