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Centre for the Southern Interior

If you are interested in more information about a particular trial, please talk with your treating physician first, and they may contact this centre for further information if necessary.

 

Tumour Group / SiteTrial TitleOpening Date
Breast



Prospective study to evaluate the feasibility of partial breast irradiation utilizing permanent breast seed implants in BC. (PBSI)May
2012
A feasibility Study of Accelerated Partial Breast Irradiation with High Dose Rate Interstitial , Multi-Catheter Brachytherapy for Women with Early Stage Breast Cancer. (HDR)March 2013
A phase III, randomized, open label, multicenter, controlled trial of niraparib versus physician’s choice in previously treated, HER 2 negative, germline BRCA mutation-positive breast cancer patients. (BRAVO) December 2014
A study of Neratinib plus Capecitabine versus Lapatinib plus Capecitabine in patients with HER2+ metastatic breast cancer who have received 2 or more prior HER2- directed regimens in the metastatic setting. (NALA) May
2015
Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant in Men and Postmenopausal Women With Advanced Breast Cancer Which Progressed on or After Aromatase Inhibitor Treatment. (SOLAR-1)May
2016
A Phase III, multi centre, randomized, placebo-controlled study of Atezolizumab (anti-PD-L1 antibody) in combination with PACLitaxel-NAB compared with placebo with PACLitaxel-NAB for patients with previously untreated metastatic triple-negative breast cancer. (IMPASSION)July
2016
Central Nervous System (CNS)Feasibility study of randomization to 20 GY in 5 fractions whole brain radiotherapy versus 15 GY in one fraction for one to ten brain metastases. (BRAT STUDY)March
2015
Colorectal cancer tissue banking study.January 2012
A phase II/III trial of Neoadjuvant Folfox, with selective use of combined modality chemoradiation versus preoperative combined modality chemoradiation for locally advanced rectal cancer patients cancer patients undergoing low anterior resection with total mesorectal excision.
(NCIC CRC.7) 
April
2014
GU - BladderA Phase III, Randomized, Open-label, Controlled, Multi-Center, Global Study of First-Line MEDI4736 Monotherapy and MEDI4736 in Combination With Tremelimumab Versus Standard of Care Chemotherapy in Patients With Unresectable Stage IV Urothelial Bladder Cancer (DANUBE)June
2016
GU- ProstateImproving QOL after optimal RT for intermediate & high risk prostate ca: HDR vs. LDR Brachytherapy Boost.
(QOL study)
December
2013
A phase II, randomized multi-centre study of cabazitaxel vs abiraterone or enzalutamide in poor prognosis-metastatic castrate-resistant prostate cancer. (OZM-054)
February
2015
​A multinational, phase III, randomized, double-blind study to evaluate the efficacy and safety of Enzalutamide plus ADT versus placebo plus ADT in subjects with metastatic hormone sensitive prostate cancer (mHSPC)May
2017​
GU - Renal 
GU - Multi 
GyneA Randomized Placebo Controlled Phase ll trial Comparing Gemcitabine Monotherapy to Gemcitabine in Combination with AZD1775 (MK1775) PO in Women with Recurrent Platinum Resistant Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancers. (PHL-093)
September
2015
LungA phase II study of Pembrolizumab in patients with advanced Malignant Pleural Mesothelioma (MPM). To evaluate whether pembrolizumab, alone or together with standard chemotherapy improves progression free survival in MPM.
(IND227)
February
2017
Lymphoma

Multiple Myeloma  
Melanoma

Multi-siteThe OncoPanel Pilot Study. (TOP)
April
2015
Supportive / Palliative Care
 
A randomized double-blind, double-dummy, 2-treatment, 2-period, cross-over comparison of sennosides and polyethylene glycol for constipation in outpatients with cancer. (Sennosides PEG)
August
2010
SOURCE: Centre for the Southern Interior ( )
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