This is an uncommon subtype of cervical carcinoma with a very high risk of distal metastatic spread even with apparent early-stage disease and has low 5-year survival. Urgent referral to Gynecologic Oncology is advised.  Patients are treated along a paradigm similar to other small cell cancers which includes cisplatin- and etoposide-based chemotherapy and radiotherapy to the pelvis +/- para-aortic regions to try to improve both local and systemic control. Defi​nitive surgery may or may not be recommended. Patient management plans should be discussed in multi-disciplinary setting with medical, radiation and surgical gynecologic oncology. 

Prophylactic cranial irradiation is not routinely recommended for small cell carcinoma of cervix.

Due to aggressive behaviour and high relapse risk, patients should undergo close follow-up. Surveillance imaging as part of follow up can be considered in selected patients.