Radiation therapy should be considered early for patients with spine metastases which are symptomatic or associated with significant vertebral body compression or paraspinal mass, so as to minimize the risk of debilitating spinal cord compression. Palliative TURP is indicated for patients in retention or with significant obstructive symptoms, or bleeding, but there may be an increased risk of postoperative incontinence secondary to sphincteric invasion.

Radiation therapy may relieve other symptomatic sites particularly in the setting of hormone refractory disease. For patients with incurable disease but locally extensive and potentially troublesome tumour burden in the prostate, radiation therapy can provide effective local control.​