Disease in the pregnant woman is generally managed as in the non-pregnant woman. The treatment policies must be individualized as to the stage and extent of disease, gestational age, and particularly the wishes of the patient by the multidisciplinary team.

Cervical screening and referral for colposcopy should be performed as per screening guidelines. Colposcopic guided biopsy of suspicious areas is recommended only if there is clinical suspicion of malignancy. An ECC should not be performed during pregnancy. If there is no clinical suspicion for malignancy, colposcopy should be repeated every trimester and again 2-3 months post​partum.

Should invasive carcinoma be discovered in early pregnancy and thought to be unsuitable for primary surgical therapy, termination of the pregnancy is usually carried out with the method depending on the gestational age and is followed by radiotherapy +/- chemotherapy. Patients with suspected clinical stage IA1 disease may be treated primarily with a cone biopsy. This should be performed after the first trimester to minimize complications and risks to the pregnancy.

If more advanced disease is suspected, options for management include radical hysterectomy with fetus in situ and pelvic lymphadenectomy, or delay of definitive treatment to allow for fetal maturity. In the latter situation, neoadjuvant chemotherapy during the pregnancy should be considered. For those patients diagnosed in the latter stage of pregnancy with a viable fetus, delivery by caesarean section is usually recommended although studies have not shown that vaginal delivery has produced a higher morbidity or decreased survival in patients delivered this way.