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Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Added 06 March 2013

All cases considered for HIPEC need to be reviewed in a multidisciplinary tumour conference.

HIPEC is not an option in the following cases:

​Absolute contraindications

  • ECOG > 2
  • Non appendiceal/colorectal/mesothelial primary
  • Unresectable disease on preoperative imaging
  • Extra-abdominal metastases
  • Multifocal malignant small bowel obstruction
  • Co-morbidities precluding extensive surgery (renal failure, cardiac disease, COPD, other)

Relative contraindications

  • Age >70 years
  • Extensive disease not amenable for R0/1 resection
  • Synchronous liver metastases
  • Progression while on chemotherapy
  • High-grade adenocarcinoma
  • Sarcomatoid variant of peritoneal mesothelioma
  • Bilateral hydronephrosis


SOURCE: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) ( )
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