Added 06 March 2013

All cases considered for HIPEC need to be reviewed in a multidisciplinary tumour conference.

HIPEC is not an option in the following cases:

Absolute contraindications

• ECOG > 2
• Non appendiceal/colorectal/mesothelial primary
• Unresectable disease on preoperative imaging
• Extra-abdominal metastases
• Multifocal malignant small bowel obstruction
• Co-morbidities precluding extensive surgery (renal failure, cardiac disease, COPD, other)

Relative contraindications

• Age >70 years
• Extensive disease not amenable for R0/1 resection
• Synchronous liver metastases
• Progression while on chemotherapy
• High-grade adenocarcinoma
• Sarcomatoid variant of peritoneal mesothelioma
• Bilateral hydronephrosis