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Pathology

​Revised 05 Sept 2012

(per College of American Pathologists 2012)

Specimen: specify

  • Type
  • Procedure
  • Length

Tumour: specify

  • Site
  • Size
  • Macroscopic tumour perforation
  • Macroscopic intactness of the mesorectum
  • Histologic type
  • Histologic grade
  • Microscopic tumour depth of invasion
  • Margins: proximal, distal, circumferential
  • Treatment effect (if neoadjuvant therapy given)
  • Lymph nodes: number examined (minimum 12 recommended), number involved
  • Lymphovascular invasion
  • Perineural invasion
  • Tumour deposits (discontinuous extramural extension)
  • Type of polyp in which invasive carcinoma arose
  • pTNM per AJCC 7th Edition

Additional pathologic findings of interest:

Histologic features suggestive of Microsatellite Instability

  • Intratumoural lymphocyte response
  • Peritumoural lymphocyte response
  • Tumour subtype: mucinous, medullary, high histologic grade

Immunohistochemistry studies for Mismatch Repair Proteins

  • MLH1
  • MSH2
  • MSH6
  • PMS2

Mutational analysis

  • KRAS
  • BRAF

SOURCE: Pathology ( )
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