Revised 05 Sept 2012

(per College of American Pathologists 2012)

Specimen: specify

• Type
• Procedure
  
• Length

Tumour: specify

• Site
• Size
• Macroscopic tumour perforation
• Macroscopic intactness of the mesorectum
• Histologic type
• Histologic grade
• Microscopic tumour depth of invasion
• Margins: proximal, distal, circumferential
• Treatment effect (if neoadjuvant therapy given)
• Lymph nodes: number examined (minimum 12 recommended), number involved
• Lymphovascular invasion
• Perineural invasion
• Tumour deposits (discontinuous extramural extension)
• Type of polyp in which invasive carcinoma arose
• pTNM per AJCC 7^th Edition

Additional pathologic findings of interest:

Histologic features suggestive of Microsatellite Instability

• Intratumoral lymphocyte response
• Peritumoral lymphocyte response
• Tumour subtype: mucinous, medullary, high histologic grade

Immunohistochemistry studies for Mismatch Repair Proteins

• MLH1
• MSH2
• MSH6
• PMS2

Mutational analysis

• KRAS
• BRAF