CAR T-cell therapy is a type of immunotherapy used to treat certain blood cancers.
A patient's T-cells (a type of white blood cell) are removed and taken to a laboratory where they are re-engineered and multiplied to better recognize and destroy cancer cells.
The changed cells, called chimeric antigen receptor (CAR) T-cells, are then infused back into the patient. This is often referred to as a "living therapy" as the CAR T-cells continue to multiply in the body, offering the possibility of long-lasting protection against cancer.
Visit the Leukemia & Lymphoma Society of Canada to watch a video about how CAR T-cell therapy works.
CAR T-cell therapy has been approved and funded for individuals with certain blood cancers that have not responded to or returned following prior treatments.
This treatment is unique in that it is designed to attack very specific types of cancer cells. Currently available CAR T products cannot be used to treat non-blood cancers. It is very similar to how vaccines are designed to prevent specific infections.
CAR T-cell therapy for solid tumours is under study and may be possible in the future.
Patients who do not meet the eligibility criteria may have access to other therapies, including clinical trials. You can discuss this further with your care team to learn more.
Standard of care CAR T-cell therapy is available in BC for pediatric patients and adult patients in a limited capacity.
Treatment for adult patients is administered at Vancouver General Hospital and BC Children's Hospital for pediatric patients (under 18 years old).
Depending on hospital capacity, some adult patients will need to travel out-of-province for this treatment.
You need a referral from your BC cancer specialist to receive this treatment.
Ask your health care team to see if you may be eligible for CAR T-cell therapy. If they think that this treatment is appropriate for you, your cancer doctor will submit a request on your behalf.
Physicians, see referrals page for guidelines on referring a patient as well as detailed instructions and forms.
For more information on CAR T in BC please visit Vancouver General Hospital and BC Children's Hospital's websites.
