The correct answer is 3.
Rationale: Based on GOOVCATX protocol, "Dose Modification, Hematology": If ANC is greater than or equal to 1.5, and Platelets are greater than or equal to 100 at nadir, the dose of PACLitaxel is given at 100% and CARBOplatin may be given at 120%. Note that this is 120% of the dose from the previous cycle that was calculated based on the renogram GFR.
As per BC Cancer Policy III-10, the BSA calculated at Cycle 1 is used for subsequent cycles, but BSA recalculation is warranted when weight changes are greater than 10%. In this case, the PACLitaxel dose does not have to change as the weight only decreased by 8.3%, and her Cycle 1 PACLitaxel dose was otherwise well tolerated.
Calculated dose of CARBOplatin:
120% x 810 mg = 972 mg
Dose ordered by physician = 970 mg (rounded down)
There is less than 5% difference between the two calculated doses, so the dose ordered is acceptable.