he correct answer is 3.
Rationale: Based on the GOOVCATX protocol "Dose Modifications, Hematology" section: if ANC is greater than or equal to 1.0, and Platelets are greater than or equal to 100, treat as per nadir. At nadir, ANC was 0.9 and platelets were 88 which means both PACLitaxel and CARBOplatin may be given at 100%. Note that this is 100% of the dose from the previous cycle that was calculated based on the previous GFR.
As per BC Cancer Policy III-10, the BSA calculated at Cycle 1 can be used for subsequent cycles. BSA recalculation for weight changes is warranted when weight changes are greater than 10%. In this case, the weight only decreased by 8.3% so the PACLitaxel dose does not have to change as it was otherwise well tolerated.
As per the GOOVCATX protocol "Treatment" section: GFR should be recalculated if creatinine increases by greater than 20% or rises above the upper limit of normal. In this case, the small creatinine increase does not warrant a recalculation.