BC Cancer uses both the traditional Durie and Salmon staging and the International Staging System (ISS) (Greipp, J Clin Oncol, 2005;23:3412). For ISS staging, the albumin can be obtained from the SPE.
Durie Salmon Staging
| Stage | Findings |
| 1 | Hgb > 100 g/L Calcium < 2.88 mmol/L Bones = no more than 1 lytic lesion |
| M-protein: IgG < 50 g/L IgA < 30 g/L |
| Total urinary light chain < 4 g/24 h |
| 2 | Between 1 and 3 |
| 3 | Any one of these: |
| Hgb < 85 g/L Calcium > 2.88 mmol/L Bones = multiple lytic lesions |
| M-protein: IgG > 70 g/L IgA > 50 g/L |
| Total urinary light chain > 12 g/24 h |
| A = creatinine<180 mmol/ |
| B = creatinine > 180 mmol/L
|
International Staging System
| Stage | Findings |
| 1 | Serum beta-2microglobulin < 3.5 mg/L and serum albumin ≥ 35 g/L |
| 2 | Serum beta-2microglobulin < 3.5 mg/L and serum albumin < 35 g/L or |
| Serum beta-2microglobulin 3.5 to < 5.5 mg/L |
| 3 | Serum beta-2microglobulin ≥ 5.5 mg/L |
