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Staging

BC Cancer uses both the traditional Durie and Salmon staging and the International Staging System (ISS) (Greipp, J Clin Oncol, 2005;23:3412). For ISS staging, the albumin can be obtained from the SPE.

Durie Salmon Staging

Stage   Findings
1Hgb > 100 g/L Calcium < 2.88 mmol/L Bones = no more than 1 lytic lesion
M-protein: IgG < 50 g/L IgA < 30 g/L
Total urinary light chain < 4 g/24 h
2Between 1 and 3
3Any one of these:
Hgb < 85 g/L Calcium > 2.88 mmol/L Bones = multiple lytic lesions

M-protein: IgG > 70 g/L IgA > 50 g/L

Total urinary light chain > 12 g/24 h
A = creatinine<180 mmol/
B = creatinine > 180 mmol/L

International Staging System

Stage  Findings
1 Serum beta-2microglobulin < 3.5 mg/L and serum albumin ≥ 35 g/L
2 Serum beta-2microglobulin < 3.5 mg/L and serum albumin < 35 g/L or
 Serum beta-2microglobulin 3.5 to < 5.5 mg/L
3 Serum beta-2microglobulin ≥ 5.5 mg/L
SOURCE: Staging ( )
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